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Martinez-Sanchez, Mariana E; Hiriart, Marcia; Alvarez-Buylla, Elena R (2017)

THE CD4+T CELL REGULATORY NETWORK MEDIATES INFLAMMATORY RESPONSES DURING ACUTE HYPERINSULINEMIA: A SIMULATION STUDY

BMC Syst Biol 11():
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Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-level mechanisms that alter CD4+ T cell differentiation and plasticity are not well understood.