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Sanchez-Moreno, Ana; Guevara-Hernandez, Eduardo; Contreras-Cervera, Ricardo; Rangel-Yescasl, Gisela; Ladron-de-Guevara, Ernesto; Rosenbaum, Tamara; Islas, Leon D (2018)

IRREVERSIBLE TEMPERATURE GATING IN TRPV1 SHEDS LIGHT ON CHANNEL ACTIVATION

Elife 7():
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Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening.