© 2018 Elsevier B.V. In this chapter, we present evidence showing that dopaminergic activity is involved in object recognition memory and object location memory tasks within structures of the temporal lobe. Dopaminergic activity within the perirhinal and insular cortices enables the consolidation of information from individual discrete stimuli, i.e., objects, whereas dopamine activity in the hippocampus is necessary to recognize the contextual information about objects. To support these differential implications, we discuss studies using in vivo microdialysis and pharmacological manipulations that test the role of dopaminergic activity on object recognition and object location memories. This review aims to demonstrate how dopaminergic activity in the temporal lobe is involved in the discrimination of the novelty/familiarity traits of the stimuli, as well as in the contextual determinants of recognition memory. We also propose that reduced catecholaminergic activity could be involved in the early deterioration process of Alzheimer's disease that impairs recognition memory.
Última actualización: 24/05/2019