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Alfonzo-Mendez, Marco A; Alcantara-Hernandez, Rocio; Adolfo Garcia-Sainz, J (2017)

NOVEL STRUCTURAL APPROACHES TO STUDY GPCR REGULATION

Int J Mol Sci 18(1):
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Upon natural agonist or pharmacological stimulation, G protein-coupled receptors (GPCRs) are subjected to posttranslational modifications, such as phosphorylation and ubiquitination. These posttranslational modifications allow protein-protein interactions that turn off and/or switch receptor signaling as well as trigger receptor internalization, recycling or degradation, among other responses. Characterization of these processes is essential to unravel the function and regulation of GPCR.