The α (1A)-adrenergic receptor, encoded by ADRA1A, couples to heterotrimeric G(q/11) proteins, promoting intracellular calcium mobilization and PKC activation. In human hepatocytes, it regulates acute metabolic responses and impacts gene expression. Although fundamental hepatic functions of ADRA1A have been described, its role in hepatocellular carcinoma remains elusive. We hypothesized that ADRA1A expressed in liver cancer tissue is part of a signaling repertoire potentially linked to patient outcomes. We analyzed The Cancer Genome Atlas liver cancer datasets and found ADRA1A gene deletion in 6