Effects of topological domain disruption on transcriptional regulation are chromatin context dependent.
Cerecedo-Castillo, Á. J., Mojica-Santamaría, D. I., Núñez-Martínez, H. N., Peralta-Alvarez, C. A., Tapia-Urzúa, G., Guerrero, G., Arzate-Mejía, R. G., & Recillas-Targa, F. (2026). Effects of topological domain disruption on transcriptional regulation are chromatin context dependent. Epigenetics & Chromatin, 19(1). https://doi.org/10.1186/s13072-026-00660-7
ABSTRACT
Three-dimensional genome organization helps coordinate enhancer-promoter communication while insulating loci from inappropriate regulatory contacts. CTCF and cohesin contribute to this organization by forming topologically associating domains. However, how boundary elements at individual loci influence transcription remains context dependent.