Antidepressants interact with an LPA3 receptor binding site: Functional and docking studies
Solís, K. Helivier; Jardón-Ibañez, Ana I.; Romero-Ávila, M. Teresa; Rincón-Heredia, Ruth; Romero-Romero, Sergio; Correa-Basurto, José; García-Sáinz, J. Adolfo (2026). Antidepressants interact with an LPA3 receptor binding site: Functional and docking studies Eur. J. Pharmacol. 1021
ABSTRACT
The effects of the antidepressants imipramine, amitriptyline, and paroxetine on LPA<sub>3</sub> receptors were studied in cellulo , using receptor-transfected HEK 293 Flp-In TREx cells, and in silico , through docking simulations. These drugs showed a low affinity for LPA<sub>3</sub> receptors with lesser efficacy than LPA (paroxetine ≈ 60