Pramipexole promotes CD8+ regulatory T cell-dependent neuroprotection in Parkinson's disease patients.
Gallegos-Altamirano, E., Castillo-Arellano, J., Pérez Figueroa, E., Guevara-Salinas, A., González-Vilchis, E., Morales-Ruiz, V., Álvarez-Luquin, D., Rodríguez-Violante, M., Ichikawa-Escamilla, E., Regalado-Mustafa, A. Y., Romero-Rodríguez, D., Martínez-Martínez, E., Velasco, I., & Adalid-Peralta, L. (2026). Pramipexole promotes CD8+ regulatory T cell-dependent neuroprotection in Parkinson?s disease patients. Brain, Behavior, and Immunity, 137, 106840. https://doi.org/10.1016/j.bbi.2026.106840
Parkinson's disease (PD) is caused by the death of dopaminergic neurons. Since immune system cells express dopamine receptors, dopaminergic agonists may modify their function. However, the effects of dopaminergic agonists on immunoregulation and the specific dopamine receptors involved are unknown.