Differential DNA methylation and CTCF binding between the ESR1 promoter a of MCF-7 and MDA-MB-231 breast cancer cells.

Montes-de-Oca-Fuentes, E. V., Jácome-López, K., Zarco-Mendoza, A., Guerrero, G., Ventura-Gallegos, J. L., Juárez-Méndez, S., Cabrera-Quintero, A. J., Recillas-Targa, F., & Zentella-Dehesa, A. (2024). Differential DNA methylation and CTCF binding between the ESR1 promoter a of MCF-7 and MDA-MB-231 breast cancer cells. Molecular Biology Reports, 51(1). https://doi.org/10.1007/s11033-023-09171-0

ABSTRACT

ESR1 is expressed by 60-70% of breast tumours. it's a good prognosis factor and the target of hormone therapy. Optimization of ESR1 reactivation therapy is currently ongoing. Here we probe if the transcription factor CTCF plays a role in the differential expression of ESR1 in the breast cancer cell lines MCF-7 (ESR1+) and MDA-MB-231 (ESR1-).



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