A self-aggregating peptide: Implications for the development of thermostable vaccine candidates
Cruz-Reséndiz, A., Zepeda-Cervantes, J., Sampieri, A., Bastián-Eugenio, C., Acero, G., Sánchez-Betancourt, J. I., ? Vaca, L. (2020). A self-aggregating peptide: implications for the development of thermostable vaccine candidates. BMC Biotechnology, 20(1). doi:10.1186/s12896-019-0592-9
The use of biomaterials has been expanded to improve the characteristics of vaccines. Recently we have identified that the peptide PH from polyhedrin self-aggregates and incorporates foreign proteins to form particles. We have proposed that this peptide can be used as an antigen carrying system for vaccines. However, the immune response generated by the antigen fused to the peptide has not been fully characterized. In addition, the adjuvant effect and thermostability of the particles has not been evaluated.