Differential DNA methylation and CTCF binding between the ESR1 promoter a of MCF-7 and MDA-MB-231 breast cancer cells.
Montes-de-Oca-Fuentes EV; Jacome-Lopez K; Zarco-Mendoza A; Guerrero G; Ventura-Gallegos JL; Juarez-Mendez S; Cabrera-Quintero AJ; Recillas-Targa F; Zentella-Dehesa A (2024). Differential DNA methylation and CTCF binding between the ESR1 promoter a of MCF-7 and MDA-MB-231 breast cancer cells. Mol Biol Rep 51 :148
ABSTRACT
ESR1 is expressed by 60-70% of breast tumours. it's a good prognosis factor and the target of hormone therapy. Optimization of ESR1 reactivation therapy is currently ongoing. Here we probe if the transcription factor CTCF plays a role in the differential expression of ESR1 in the breast cancer cell lines MCF-7 (ESR1+) and MDA-MB-231 (ESR1-).