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Miranda-Astudillo, Hector; Ostolga-Chavarria, Marcos; Cardol, Pierre; Gonzalez-Halphen, Diego (2022)

BEYOND BEING AN ENERGY SUPPLIER, ATP SYNTHASE IS A SCULPTOR OF MITOCHONDRIAL CRISTAE

Biochim Biophys Acta Bioenerg 1863(6):
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Mitochondrial FF-ATP synthase plays a key role in cellular bioenergetics; this enzyme is present in all eukaryotic linages except in amitochondriate organisms. Despite its ancestral origin, traceable to the alpha proteobacterial endosymbiotic event, the actual structural diversity of these complexes, due to large differences in their polypeptide composition, reflects an important evolutionary divergence between eukaryotic lineages. We discuss the effect of these structural differences on the oligomerization of the complex and the shape of mitochondrial cristae.